Expression of Neural Cell Adhesion Molecule L1 in Human Lung Cancer Cell Lines.
نویسندگان
چکیده
منابع مشابه
Clinical mutations in the L1 neural cell adhesion molecule affect cell-surface expression.
Mutations in the L1 neural cell adhesion molecule, a transmembrane glycoprotein, cause a spectrum of congenital neurological syndromes, ranging from hydrocephalus to mental retardation. Many of these mutations are single amino acid changes that are distributed throughout the various domains of the protein. Defective herpes simplex virus vectors were used to express L1 protein with the clinical ...
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PURPOSE Non-small cell lung cancer (NSCLC) is a highly metastatic cancer with limited treatment options, thus requiring development of novel targeted therapies. Our group previously identified L1 cell adhesion molecule (L1CAM) expression as a member of a prognostic multigene expression signature for NSCLC patients. However, there is little information on the biologic function of L1CAM in lung c...
متن کاملL1 Cell Adhesion Molecule (L1CAM) Promotes Tumorigenicity and Metastatic Potential in Non-Small-Cell Lung Cancer
Running Title: L1CAM in non-small cell lung cancer Author manuscripts have been peer reviewed and accepted for publication but have not yet been edited. Abstract Purpose: Non-small-cell lung cancer (NSCLC) is a highly metastatic cancer with limited treatment options, thus requiring development of novel targeted therapies. Our group previously identified L1 cell adhesion molecule (L1CAM) express...
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Purpose: Non–small cell lung cancer (NSCLC) is a highly metastatic cancer with limited treatment options, thus requiring development of novel targeted therapies. Our group previously identified L1 cell adhesion molecule (L1CAM) expression as a member of a prognostic multigene expression signature for NSCLCpatients. However, there is little information on the biologic function of L1CAM in lung c...
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Background: Heme oxygenase-1 (HO-1) is a cytoprotective and antiapoptotic enzyme, which has been involved in maintaining cellular homeostasis, and plays an important protective role by modulating oxidative injury. Up-regulation of (HO-1) has contributed to tumorogenicity of some cancers. In this study we investigated the expression pattern of the HO-1, in five different human-derived cancer cel...
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ژورنال
عنوان ژورنال: Cell Structure and Function
سال: 1997
ISSN: 0386-7196,1347-3700
DOI: 10.1247/csf.22.511